Which SARI medication is known to block both serotonin reuptake and has a sleep-inducing effect?

Trazodone is recognized as a serotonin antagonist and reuptake inhibitor (SARI) that effectively blocks the reuptake of serotonin, increasing its availability in the synaptic cleft and enhancing serotonergic neurotransmission. In addition to its action on serotonin, trazodone possesses sedative properties, primarily due to its antagonism of the serotonin 2A receptors and its influence on other neurotransmitter systems. These sedative effects make it particularly useful in treating insomnia and other sleep disturbances, often seen in patients with depression or anxiety.

The other medications mentioned have different mechanisms and uses. For instance, sertraline is a selective serotonin reuptake inhibitor (SSRI) primarily used for depression and anxiety disorders, lacking the pronounced sedative effect seen with trazodone. Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) that is generally stimulating rather than sedating, making it less appropriate for sleep issues. Duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI), is focused on treating depression and chronic pain and does not have sleep-inducing properties like trazodone.

Thus, trazodone's dual role as a serotonin reuptake blocker combined with