Which of the following psychiatric diagnoses can be associated with changes or losses in grey matter?

Alzheimer's disease, schizophrenia, and major depressive disorder are indeed associated with changes or losses in grey matter. In Alzheimer's disease, neurodegeneration leads to significant reduction in grey matter as brain cells die and the overall mass of the brain decreases. Research has shown marked atrophy in specific areas of the brain, particularly in the hippocampus and cortex, which are critical for memory and cognitive function.

In schizophrenia, studies have observed consistent reductions in grey matter volumes in various brain regions including the prefrontal cortex and temporal lobes, which have implications for cognitive deficits and positive/negative symptoms associated with the disorder.

Major depressive disorder has also been linked to changes in grey matter, particularly in areas such as the prefrontal cortex, hippocampus, and amygdala, which are involved in emotional regulation, cognition, and stress response. These findings underline the neurobiological aspects of depression, contributing to our understanding of its pathophysiology.

Overall, the grouping of these three disorders illustrates a relationship between alterations in brain structure, specifically grey matter changes, and significant psychiatric conditions.