Which of the following medications is associated with a duration of action of 3-5 hours when used intravenously?

The correct choice reflects the pharmacokinetic properties of fentanyl when administered intravenously. Fentanyl is a potent synthetic opioid that acts quickly and typically has a duration of action ranging from 3 to 5 hours. This relatively short duration is one reason it is often used in acute care settings, such as during surgeries or for the management of breakthrough pain in patients already receiving opioid therapy.

Fentanyl’s rapid onset and relatively short duration allow for flexible dosing and quick titration based on patient response, making it suitable for various clinical situations. The effectiveness of fentanyl is also influenced by its high lipid solubility, which facilitates its rapid absorption and action in the central nervous system.

While other opioids listed can also be used for pain management, their durations of action differ significantly. For instance, meperidine has a shorter half-life and can lead to neurotoxic effects if used repeatedly due to its metabolite. Hydromorphone and methadone have longer durations of action compared to fentanyl, especially methadone, which can last significantly longer due to its unique pharmacokinetics and half-life. Thus, fentanyl’s 3-5 hour duration of action accurately characterizes its clinical use and distinguishes it from the