Which of the following medications poses a risk for orthostatic hypotension?

Quetiapine is known to pose a risk for orthostatic hypotension due to its alpha-1 adrenergic blocking effects. This medication, which is an atypical antipsychotic, acts on various neurotransmitter receptors, including serotonin and norepinephrine receptors. The interaction with alpha-1 receptors can lead to vasodilation and decreased systemic vascular resistance, particularly upon standing, resulting in a drop in blood pressure.

This phenomenon is particularly relevant in individuals who may already have compromised blood pressure regulation or those who are dose-sensitive to the medication. Awareness of this side effect is critical in clinical practice, especially in patients who may be vulnerable to falls or other complications associated with sudden drops in blood pressure. Monitoring patients for signs of orthostatic hypotension when initiating treatment with quetiapine or adjusting its doses is, therefore, an important aspect of management.