Which of the following is a MAOI drug?

Prepare for the Advanced Pharmacology – Psychopharmacology exam. Study with interactive quizzes, flashcards, and detailed explanations for each question. Enhance your understanding and ace your test!

Phenelzine (Nardil) is a monoamine oxidase inhibitor (MAOI) that is primarily used for the treatment of major depressive disorder and anxiety disorders, particularly when other treatments have failed. The significance of MAOIs lies in their mechanism of action, which involves the irreversible inhibition of monoamine oxidase enzymes. These enzymes are responsible for the breakdown of neurotransmitters such as serotonin, norepinephrine, and dopamine. By inhibiting their action, MAOIs can lead to increased levels of these neurotransmitters in the synaptic cleft, thereby enhancing mood and alleviating symptoms of depression and anxiety.

Other options presented are not MAOIs, but rather belong to different classes of antidepressants. Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI), which increases serotonin levels by blocking its reuptake into the presynaptic cell. Duloxetine (Cymbalta) is a serotonin-norepinephrine reuptake inhibitor (SNRI), which impacts both serotonin and norepinephrine levels. Fluoxetine (Prozac) is another SSRI that functions similarly to sertraline. While these medications are effective for treating depression, their mechanisms differ significantly from that of

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