Which of the following is the most common SARI that blocks histaminergic and α-adrenergic receptors?

Trazodone is identified as the most common serotonin antagonist and reuptake inhibitor (SARI) that also has the ability to block histaminergic and alpha-adrenergic receptors. This dual action contributes to its effectiveness in treating major depressive disorder and anxiety disorders, particularly in patients who also have sleep disturbances due to its sedative properties.

The mechanism of action of trazodone involves the inhibition of serotonin reuptake, which increases serotonin levels in the synaptic cleft, improving mood. Additionally, its antagonism of histamine H1 receptors contributes to its sedative effects, making it useful for treating insomnia, which is a common symptom in depression. The blockade of alpha-adrenergic receptors can also lead to a reduction in anxiety through a calming effect.

In contrast, drugs like sertraline and fluoxetine are selective serotonin reuptake inhibitors (SSRIs) that primarily increase serotonin levels without significant blockage of these other receptors, thereby lacking the sedative effects associated with histamine receptor antagonism. Bupropion, while an effective antidepressant, primarily works as a norepinephrine and dopamine reuptake inhibitor and does not function as a SARI.

Overall, trazodone’s unique combination of properties makes