Which of the following combinations is indicated for combination therapy in nicotine addiction?

The combination of a nicotine patch and oral bupropion is indicated for use in combination therapy for nicotine addiction because both agents address the neurobiological aspects of nicotine dependence effectively.

The nicotine patch provides a steady release of nicotine, which helps to alleviate withdrawal symptoms and reduces cravings without the harmful substances found in combustible tobacco products. Bupropion, on the other hand, is an atypical antidepressant that also acts as a smoking cessation aid by modulating neurotransmitters in the brain. It specifically helps to reduce withdrawal symptoms and cravings, making it easier for individuals to quit smoking.

Utilizing both the nicotine patch and bupropion together enhances the overall effectiveness of treatment, offering a multi-faceted approach that targets both the physiological and psychological components of nicotine addiction. This combination has been shown in studies to increase the likelihood of successful smoking cessation compared to using either therapy alone.

Other combinations in the list do not serve the same therapeutic purpose for nicotine addiction. For instance, combining the nicotine patch with alcohol may lead to increased risk of relapse in smoking behavior and does not support cessation efforts. Similarly, the use of inhaled steroids or antipsychotics does not address nicotine dependence and may not provide any synergistic benefit in managing withdrawal