Which Nicotine Replacement Therapy method provides buccal absorption?

Nicotine gum is designed to facilitate buccal absorption, meaning the nicotine is absorbed through the mucous membranes in the mouth. When the gum is chewed, it releases nicotine, which then diffuses across the buccal mucosa, allowing it to enter the bloodstream directly. This method provides a quicker onset of nicotine action compared to methods that require systemic absorption through the gastrointestinal tract, like the nicotine patch or lozenge.

Nicotine patches are designed for transdermal absorption through the skin, delivering a steady dose of nicotine over an extended period. The nicotine lozenge also allows for oral delivery but primarily absorbs through the gastrointestinal tract rather than directly through buccal mucosa. The nicotine inhaler mimics the experience of smoking by delivering nicotine vapor to the lungs, but it does not primarily rely on buccal absorption. Therefore, nicotine gum is the method specifically designed for buccal absorption.