Which neurotransmitter is majorly involved in the mesolimbic pathway?

The mesolimbic pathway is primarily associated with the neurotransmitter dopamine. This pathway is one of the key routes in the brain that plays a significant role in the reward system, motivation, and the regulation of emotions. Dopamine release in the mesolimbic pathway is linked to feelings of pleasure, reinforcement, and the processing of rewarding stimuli, which is particularly relevant in various psychiatric disorders, including schizophrenia and addiction.

In the context of psychopharmacology, drugs that affect dopamine transmission in the mesolimbic pathway can lead to therapeutic effects in conditions such as schizophrenia, where dopaminergic dysregulation occurs. The emphasis on dopamine in this pathway underscores its importance in understanding the neurobiology behind both normal and abnormal behaviors. Other neurotransmitters listed may have their own functions in different pathways or systems but are not the primary mediators in the mesolimbic pathway.