Which medication may be used for both smoking cessation and depression?

Bupropion is a unique medication that serves as an effective treatment option for both smoking cessation and depression. It functions as a norepinephrine-dopamine reuptake inhibitor (NDRI) and is known for its stimulating properties, which can enhance mood and reduce symptoms of depression. In the context of smoking cessation, bupropion has been found to help reduce withdrawal symptoms and cravings by targeting the same pathways in the brain that nicotine does.

This dual action makes bupropion particularly valuable in clinical practice, especially in patients who may be dealing with both depression and a desire to quit smoking. Moreover, its antidepressant effects can help manage mood and emotional stability as individuals go through the challenges of quitting smoking.

Other medications mentioned have specific uses but do not encompass the dual indication of treating both smoking cessation and depression. Varenicline is primarily for smoking cessation but does not have established antidepressant properties. Naltrexone is used for alcohol and opioid dependence, and disulfiram is used for treating alcohol use disorder, with neither indicated for depression. Thus, bupropion stands out as the correct choice for its dual efficacy.