Which medication is noted for its well-tolerated and ease of administration in treating acute agitation?

The medication noted for its well-tolerated and ease of administration in treating acute agitation is actually olanzapine. Olanzapine is an atypical antipsychotic that has a rapid onset of action and is often used for agitated patients due to its safety profile and relatively fewer extrapyramidal side effects compared to older antipsychotics like haloperidol.

While loxapine is also effective for agitation, it may not have the same level of overall patient tolerance or ease of administration, particularly in acute settings. Aripiprazole, although useful in various psychiatric conditions, does not have as established a role in acute agitation management as olanzapine. Haloperidol, while effective, is associated with a higher incidence of extrapyramidal symptoms and may be less favored due to its side effect profile.

Hence, olanzapine stands out for its combination of rapid effectiveness, tolerability, and convenient routes of administration (e.g., oral or intramuscular), making it often the preferred choice for managing acute agitation in clinical practice.