Which condition can be exacerbated by high levels of glutamate in the brain?

High levels of glutamate in the brain are particularly linked to schizophrenia. Glutamate is the primary excitatory neurotransmitter in the central nervous system, and its dysregulation plays a significant role in various neuropsychiatric conditions. In the context of schizophrenia, an overabundance of glutamate may contribute to symptoms such as cognitive deficits and psychosis, as excessive glutamate can lead to neuronal excitotoxicity and interfere with normal synaptic transmission. This connection has been a focal point of research, leading to investigations into glutamate-modulating medications as potential treatments for schizophrenia.

While conditions like anxiety disorders, Parkinson's disease, and borderline personality disorder may involve neurotransmitter imbalances, the direct exacerbation by high glutamate levels is most prominently noted in schizophrenia. This distinctive association is central to understanding the pathophysiology of schizophrenia and the potential therapeutic strategies targeting glutamatergic systems.