Which combination contains naloxone and is designed to block the effects of buprenorphine?

The combination that contains naloxone and is specifically designed to block the effects of buprenorphine is buprenorphine plus naloxone, commonly known as Suboxone. This combination is strategically formulated to take advantage of the properties of both medications. Buprenorphine is a partial agonist at the mu-opioid receptor, providing pain relief and reducing withdrawal symptoms in individuals dependent on opioids, while naloxone is an opioid antagonist that counteracts the effects of opioids.

The inclusion of naloxone in this formulation serves a crucial purpose: it discourages misuse. If Suboxone is misused by injection, naloxone can precipitate withdrawal symptoms, thereby reducing the potential for abuse. However, when taken as prescribed (typically sublingually), the naloxone component has minimal impact due to its lower bioavailability, allowing buprenorphine to exert its intended effects.

Other combinations mentioned do not serve this specific purpose. For instance, methadone is another opioid used in addiction treatment but does not contain naloxone. Naltrexone is a full opioid antagonist used to block the effects of opioids but is not combined with buprenorphine. Lisdexamfetamine, a stimulant used