When starting bupropion (Zyban) for nicotine addiction, when should the treatment ideally begin?

Starting bupropion for nicotine addiction is ideally recommended to begin 1 to 2 weeks before the actual quit date. This timing allows the medication to reach therapeutic levels in the body, which can enhance its effectiveness in managing withdrawal symptoms and cravings associated with quitting smoking. By initiating treatment early, individuals can experience a smoother transition into cessation, as bupropion works by influencing the neurochemistry related to dopamine and norepinephrine, helping to mitigate the urge to smoke.

Beginning treatment earlier rather than on the quit date itself provides an opportunity for individuals to adjust to the medication and allows for closer monitoring of any potential side effects prior to quitting nicotine. This advance strategy also supports cognitive preparation for quitting, as individuals can focus on behavioral strategies and coping mechanisms during this lead-up period.