When initiating treatment for depression, how should the dosing be adjusted?

Gradually adjusting the dosing to the efficacious dose range is important when initiating treatment for depression because this approach allows for a careful assessment of the patient's response to the medication while minimizing the risk of adverse effects. Starting at a lower dose can help to gauge how well the patient tolerates the medication and can provide insight into whether the dose needs to be increased.

This gradual titration is critical because many antidepressants can take several weeks to show their full effect, and starting at a lower dose allows for monitoring during this period. It also permits a safer course of treatment since some patients may experience side effects that could hinder adherence if doses are increased too rapidly. By adjusting doses based on efficacy rather than solely on side effects or by switching medications hastily, healthcare providers can ensure that the patient receives the best chance at achieving a therapeutic outcome while minimizing risks.