What medication is often delivered as a monthly long-acting injection for opioid use disorder treatment?

Naltrexone is commonly administered as a monthly long-acting injection for the treatment of opioid use disorder. It is an opioid antagonist that works by blocking the euphoric effects of opioids, thereby reducing cravings and the risk of relapse in patients who are trying to maintain abstinence from opioids. The long-acting formulation allows for sustained levels of the medication in the body, which can enhance adherence to treatment and provide consistent protection against opioid use.

In contrast, the other medications listed are not typically used in the context of opioid use disorder as long-acting injections. Acamprosate is primarily used in the management of alcohol dependence, while disulfiram is also used for alcohol use disorder by inducing unpleasant reactions when alcohol is consumed. Topiramate is an anticonvulsant that has been researched for various conditions, including alcohol dependence, but it is not specifically indicated as a long-acting treatment for opioid use disorder.