What major side effect may result from the use of Norepinephrine Dopamine Reuptake Inhibitors (NDRIs)?

Norepinephrine Dopamine Reuptake Inhibitors (NDRIs) are known to have a distinct mechanism of action in comparison to other classes of antidepressants. One of the notable side effects associated with the use of NDRIs, such as bupropion, is dry mouth. This occurs due to the drug's impact on neurotransmitter activity, particularly its effects on norepinephrine and dopamine, which can alter salivary gland function leading to reduced saliva production.

While other side effects like constipation, headache, and anxiety may also be observed with NDRIs, dry mouth is particularly prevalent and significant due to its relevance in patient adherence and quality of life. Patients experiencing dry mouth may struggle with oral health issues, discomfort, or difficulties in swallowing, making it an important consideration for clinicians when prescribing medications in this class. Additionally, the dry mouth side effect can sometimes be managed with simple interventions, helping patients tolerate the medication better and continue benefiting from the therapeutic effects of NDRIs.