What is the primary method of drug delivery for the nicotine patch?

The primary method of drug delivery for the nicotine patch is transdermal absorption. This approach allows nicotine to be delivered directly through the skin and into the bloodstream over an extended period. The nicotine patch provides a slow and steady release of nicotine, which helps to reduce withdrawal symptoms and cravings associated with smoking cessation.

Transdermal delivery is particularly effective because it bypasses first-pass metabolism in the liver, which can otherwise reduce the bioavailability of the drug. The adhesive patch is designed to adhere to the skin and is typically worn for a specified duration, allowing for continuous absorption throughout the day.

Other methods such as intranasal absorption and inhalation are not used with the nicotine patch. Oral ingestion would involve the nicotine being processed by the digestive system and undergoing first-pass metabolism, making it less effective as a route for delivering nicotine in a controlled manner. Therefore, transdermal absorption is the optimal and intended delivery system for the nicotine patch.