What is the maximum dose of citalopram due to the risk of QT prolongation?

The maximum recommended dose of citalopram is 20 mg due to concerns related to QT prolongation, particularly in patients who are at higher risk for developing cardiac arrhythmias. Clinical guidelines have indicated that doses above this level can lead to significant increases in the QT interval, which can consequently increase the risk of Torsades de Pointes, a potentially life-threatening arrhythmia.

The risk of QT prolongation with citalopram is especially critical in certain populations, such as those with pre-existing heart conditions or those who are taking other medications that can affect cardiac conduction. Therefore, healthcare providers are advised to adhere to this maximum dose to promote safe prescribing practices and minimize the risk of serious cardiac side effects associated with higher doses of the medication.