What is the maximum dose of vortioxetine for a 2D6 poor metabolizer?

The maximum dose of vortioxetine for a 2D6 poor metabolizer is correctly identified as 10 mg. This is based on the pharmacogenomic considerations that guide dosing of medications affected by cytochrome P450 (CYP) enzymes. Vortioxetine is primarily metabolized by CYP2D6, and individuals identified as poor metabolizers of this enzyme may experience higher plasma concentrations of the drug, increasing the risk of adverse effects.

For patients with reduced CYP2D6 activity, it is recommended to initiate treatment at a lower dose to mitigate potential side effects, thus limiting the maximum permissible dose to 10 mg. This adjustment is essential to ensure safety and efficacy while minimizing the likelihood of toxicities associated with the drug's accumulation in the body. Therefore, for 2D6 poor metabolizers, the recommended maximum dose reflects a cautious approach to dosing that facilitates patient safety.