What is the first-line treatment for psychomotor agitation linked to alcohol withdrawal?

Benzodiazepines are the first-line treatment for psychomotor agitation associated with alcohol withdrawal due to their effectiveness in managing withdrawal symptoms and their role in preventing complications such as delirium tremens. They work by enhancing the effect of the neurotransmitter GABA, which has a calming effect on the nervous system. This is particularly important in the context of alcohol withdrawal, as individuals experiencing this condition often face increased anxiety and agitation.

Benzodiazepines not only help alleviate psychomotor agitation but also reduce the risk of seizures that may occur during withdrawal. Their rapid onset of action makes them particularly suitable for managing acute symptoms effectively. While other classes of medications like antidepressants or antipsychotics may play a role in the broader management of mental health conditions, they are not typically used as the first-line treatment for acute alcohol withdrawal symptoms. Opioids are not indicated for this condition due to the risk of further complicating the withdrawal process. Thus, benzodiazepines remain the gold standard in this scenario.