What is a significant concern with Thioridazine related to its use?

Thioridazine is a typical antipsychotic that poses a significant concern due to its potential to prolong the QT interval, which can lead to serious cardiac arrhythmias, such as Torsades de Pointes. The QT interval represents the time it takes for the heart to repolarize after a heartbeat, and when it is prolonged, the risk of arrhythmias increases significantly. This side effect is particularly important to monitor, especially in patients who may already be at risk for cardiac complications or who are taking other medications that can also prolong the QT interval.

The concern surrounding QTc prolongation emphasizes the need for careful ECG monitoring and consideration of individual patient risk factors when prescribing Thioridazine. This makes it crucial for healthcare providers to weigh the benefits of treatment against the potential for harm due to these cardiac risks.