What is a common side effect associated with MAOIs?

The correct response to the question about common side effects associated with monoamine oxidase inhibitors (MAOIs) is related to insomnia. MAOIs are a class of antidepressant medications that can influence neurotransmitter levels in the brain. One of the notable side effects of these medications is insomnia, which can occur due to their stimulating effects on the central nervous system.

Insomnia can arise from the increased levels of norepinephrine and serotonin that MAOIs facilitate by inhibiting the monoamine oxidase enzyme, which normally breaks down these neurotransmitters. This can lead to heightened arousal and therefore difficulties in sleeping.

Other side effects of MAOIs might include dietary restrictions due to hypertensive crises caused by tyramine-containing foods. While weight gain can occur with many antidepressants, it is not as specifically associated with MAOIs compared to the direct impact on sleep. Similarly, skin rash is not commonly linked to MAOIs, and increased appetite is not a typical side effect, as they are more often associated with other types of antidepressants.