What is a common side effect of Tricyclic Antidepressants related to α1-adrenergic effects?

Orthostatic hypotension is a well-documented side effect of Tricyclic Antidepressants (TCAs) that is directly linked to their α1-adrenergic antagonistic properties. TCAs can block α1-adrenergic receptors, which play a significant role in the regulation of vascular tone and blood pressure. When these receptors are inhibited, it can lead to a reduction in vascular resistance, particularly in situations where a person is standing up or suddenly changes positions, resulting in a drop in blood pressure that causes symptoms such as dizziness, lightheadedness, or fainting.

This side effect is particularly concerning in older adults or those already taking medications that can lower blood pressure or affect cardiovascular function. The awareness of this symptom is crucial for clinicians when they are prescribing TCAs, as patients need to be counseled about the potential risk of orthostatic hypotension, especially if they are prone to falls or have other underlying health issues.

Other side effects associated with TCAs, such as dry mouth, weight gain, and blurred vision, stem from different mechanisms, such as anticholinergic effects and metabolic changes, but they do not directly relate to α1-adrenergic blockade. Therefore, orthostatic hypot