What effect does Bupropion have that is distinct from other antidepressants?

Bupropion is distinct among antidepressants primarily due to its unique mechanism of action, which involves the reuptake inhibition of dopamine and norepinephrine. This is significant because many traditional antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), primarily target serotonin reuptake. The effect on dopamine is particularly noteworthy, as it can contribute to Bupropion's stimulating properties and may enhance mood as well as increase energy levels, making it a useful option for patients with symptoms of fatigue or lethargy, which are common in major depressive disorder.

Additionally, Bupropion is often used in cases where patients may have experienced sexual side effects with other antidepressants because it typically does not have these adverse effects, largely due to its different neurotransmitter targets. This distinguishes Bupropion as a versatile choice among antidepressants and offers an alternative for those who may not respond well to conventional treatments.