What effect does a serotonin and norepinephrine reuptake inhibitor have on norepinephrine levels?

A serotonin and norepinephrine reuptake inhibitor (SNRI) is designed to target the reuptake of both serotonin and norepinephrine in the synaptic cleft. By inhibiting the transporters responsible for reabsorbing these neurotransmitters back into the presynaptic neuron, SNRIs effectively increase the availability of norepinephrine in the synapse. This leads to an increase in norepinephrine levels, which is thought to contribute to their antidepressant and anxiolytic effects. By enhancing the action of norepinephrine, SNRIs can improve mood, energy levels, and other symptoms associated with mood disorders.