What effect do first-generation antipsychotics generally have on motor control?

First-generation antipsychotics, also known as typical antipsychotics, primarily exert their effects through dopamine D2 receptor antagonism. This blockade can lead to a range of side effects, particularly in the extrapyramidal system, which is responsible for coordinating voluntary motor control. As a result, these medications can cause impairments in motor control, manifesting as symptoms such as akathisia, dystonia, and tardive dyskinesia.

The impairment of motor control is a significant concern in the use of first-generation antipsychotics, as these drugs interfere with the normal functioning of neural pathways that regulate motor activity. This can lead to difficulties in movement, which is a well-documented consequence of prolonged use of these medications. Understanding this aspect is crucial for psychiatric-mental health nurse practitioners in order to manage and mitigate these side effects when treating patients with psychotic disorders.