What adverse effect occurs in approximately 40% of patients taking bupropion (Zyban)?

Bupropion, commonly prescribed as an antidepressant and smoking cessation aid, has a notable side effect profile. Insomnia occurs in around 40% of patients taking bupropion, making it a significant concern for those on this medication. This is attributed to its stimulating properties which can increase wakefulness and reduce the ability to initiate or maintain sleep.

In addition, bupropion's mechanism as a norepinephrine-dopamine reuptake inhibitor (NDRI) contributes to its stimulating effects, often resulting in increased energy levels that can interfere with sleep patterns. This side effect can be particularly challenging for patients who already experience sleep disturbances or have a history of insomnia.

While other options such as dizziness, dry mouth, and nausea are also reported side effects of bupropion, they occur with lower frequency compared to insomnia, making insomnia the most prevalent among those listed. Understanding this adverse effect is essential for patient management, enabling healthcare providers to monitor and address sleep issues proactively when prescribing bupropion.