True or False: Low-dose trazodone may be used as an adjunctive treatment for clients with major depression who have sleep difficulties.

Low-dose trazodone can indeed be used as an adjunctive treatment for clients with major depression who experience sleep difficulties. Trazodone is an antidepressant that primarily works by inhibiting the reuptake of serotonin and has sedative properties due to its antagonistic action on certain serotonin receptors and its impact on histamine receptors.

In practice, clinicians often utilize low doses of trazodone specifically to help improve sleep in patients struggling with insomnia, which can be a common symptom associated with major depressive disorder. By addressing both depressive symptoms and insomnia concurrently, trazodone can enhance overall treatment outcomes.

It's important to note that while adjunctive therapy can be beneficial, the decision to prescribe trazodone should be individualized, taking into consideration the patient's complete clinical picture, including their other medications, potential side effects, and other comorbid disorders.