Mirtazapine is primarily classified as which type of receptor agonist?

Mirtazapine is primarily classified as a serotonin norepinephrine receptor agonist, which is reflected in its mechanism of action. It exerts its therapeutic effects mainly through antagonism of central alpha-2 adrenergic receptors, which increases the release of norepinephrine and serotonin. This dual action enhances neurotransmission in pathways that improve mood and alleviate symptoms of depression.

Moreover, mirtazapine also acts on specific serotonin receptors, including 5-HT2 and 5-HT3 receptors, where it functions as an antagonist. This property contributes to its anxiolytic and sedative effects and helps reduce potential side effects often associated with other antidepressants that primarily increase serotonin levels. The pharmacological profile of mirtazapine allows it to provide relief for patients with depression, particularly those experiencing insomnia or anxiety alongside depressive symptoms, thus addressing a broader spectrum of mood and anxiety disorders.