In the context of pharmacology, which medication is used to control EPS related to haloperidol?

Promethazine is commonly used to manage extrapyramidal symptoms (EPS) that can occur with antipsychotic medications like haloperidol. EPS includes symptoms such as tremors, rigidity, and bradykinesia, which mimic Parkinson’s disease and can significantly affect a patient's quality of life. Promethazine is an antihistamine with anticholinergic properties, making it effective in counteracting these side effects.

In the context of antipsychotic use, medications like haloperidol antagonize dopamine receptors, particularly in the nigrostriatal pathway, leading to the development of EPS. By providing anticholinergic effects, promethazine helps to restore the balance between acetylcholine and dopamine, thus alleviating these symptoms.

The other drugs listed do not primarily address EPS. Diazepam is a benzodiazepine that can be used for anxiety and muscle relaxation but isn't specifically indicated for EPS. Fluoxetine is an SSRI used for depression and anxiety disorders, and while it may help with mood disturbances, it does not have an effect on EPS. Quetiapine is an atypical antipsychotic that may also help with reducing symptoms of psychosis, but it is not used specifically for managing EPS caused by