How do SSRIs affect feelings of fear and anxiety?

SSRIs, or selective serotonin reuptake inhibitors, primarily work by increasing serotonin availability in the brain. This increase is achieved through the inhibition of the reuptake process of serotonin, meaning that when serotonin is released into the synaptic cleft, it remains there longer, promoting greater activation of serotonin receptors.

The enhancement of serotonin levels is associated with improved mood and a reduction in anxiety and fear. Serotonin plays a crucial role in regulating emotions, mood, and anxiety states, and higher availability of serotonin can lead to a calming effect on the brain, thereby easing feelings of anxiety and fear.

This mechanism is particularly significant for individuals who experience anxiety disorders, as SSRIs help to restore the balance of serotonin, contributing to symptom relief and improved emotional regulation. Therefore, by increasing serotonin availability, SSRIs effectively alleviate feelings of fear and anxiety.