For a client identified as a poor metabolizer of drugs, what is the likely impact on drug concentration?

When a client is identified as a poor metabolizer of drugs, it means that their body processes medications at a slower rate than normal. This reduced metabolic capability is often due to genetic variations affecting enzymes responsible for drug metabolism, particularly those in the cytochrome P450 family.

As a result of this slower metabolism, drugs that are typically eliminated from the body at a standard rate will remain in the system longer, leading to higher concentrations in the bloodstream. This is especially significant for medications with narrow therapeutic ranges, where maintaining appropriate drug levels is critical for efficacy and the avoidance of toxicity.

In cases where the drug is usually cleared efficiently in individuals with normal metabolic capacity, a poor metabolizer's diminished ability to process the medication means they are at higher risk of experiencing elevated blood drug concentrations, potentially resulting in enhanced effects or side effects. Therefore, recognizing this metabolic characteristic is crucial for appropriate dosing and management of pharmacotherapy for these clients.