According to the National Institute on Drug Abuse, what percentage of vulnerability to substance use disorders is due to genetic factors?

The correct percentage of vulnerability to substance use disorders that is attributed to genetic factors is indeed within the range of 40-60%. This statistic highlights the significant role that genetic predisposition plays in the development of substance use disorders, suggesting that a substantial proportion of an individual's risk for developing these disorders can be explained by hereditary influences.

Research shows that genetics can affect how individuals respond to substances, their likelihood of developing dependence, and their capacity to cope with stressors that might lead them to use substances. Variations in certain genes associated with neurotransmitter systems, such as those that regulate dopamine and serotonin, contribute to this risk. This genetic vulnerability interacts with environmental factors, including social, cultural, and psychological influences, further illustrating the complexity of substance use disorders.

In contrast, the other options suggest lower percentages which do not accurately represent the current understanding of the genetic contributions to these disorders as recognized by leading health organizations such as the National Institute on Drug Abuse. This understanding underscores the need for integrated approaches in prevention and treatment that consider both genetic and environmental factors.